Bio-based value chains (BBVCs) have often been criticized for their detrimental social and environmental effects. Existing methods such as social impact assessment do not sufficiently address these negative effects because of their limited focus and lack of attention to social justice. This paper explores the contribution of Capability Sensitive Design (CSD) to designing BBVCs for social justice. CSD is a combination of Value Sensitive Design (VSD), an approach to account for human values in a design process, and the Capability Approach (CA), a normative framework that incorporates multiple dimensions of human well-being. Three case studies demonstrate how CSD can be used to make design choices in the early stages of developing new BBVCs from waste biomass. The cases explore olive oil residues in Spain, coffee and cocoa residues in Colombia, and encroacher bush in Namibia. CSD is a relatively new approach and its contribution to social justice in BBVCs remained unexplored. We show that CSD can contribute to distributive, recognition, and procedural justice by allowing the identification of local vulnerable stakeholders and providing tools to connect their needs, knowledge, and capabilities to concrete design choices.

@en

Biomass such as crops and agricultural waste is increasingly used as the primary resource for products like bioplastics and biofuels. Incorporating the needs, knowledge, skills and values of biomass producers in the design of global value chains – the steps involved in creating any finished product from design to delivery – can contribute to sustainability, reliability and fairness. However, how to involve biomass producers, especially if they are resource poor, remains a challenge. To make sure that inclusion in global biobased value chains is both fair and effective, the capabilities of relevant actors need to be taken into account, especially of those producing biomass. Access to resources determines to what extent a specific actor can participate in a global value chain. Therefore, differences in capabilities should be a central consideration when new (biobased) value chains are designed. Using the capability approach as an ethical framework to realize inclusion, we discern three complementary strategies for setting up inclusive value chains. Firstly, designing for local conversion factors second, providing adaptive design for new capabilities, and third, investing in local conversion factors. Applying these strategies can lead to context-sensitive design of biorefineries that allow for true inclusion of local stakeholders. We support these claims with reference to case-studies of sugarcane production in Jamaica, modified tobacco in South Africa and the non-edible parts of corn (stover) in the US.

@en

Data-centric biology is taking a great leap, thanks to developments in omics technologies and the ever expanding genomic sequencing databases which consist of so-called Digital Sequence Information (DSI). DSI is derived from the sequencing of living organisms such as microbes, plants and animals. These data in turn feed into machine learning approaches, which help to sophisticate engineering of living organisms. These developments go hand in hand with the Open Science movement that urges scientists to share their data as much as possible, following the principle that more data is always better and will lead to more scientific insights. However, these developments risk increasing the digital divide between scientists with access to sufficient resources to generate and analyse DSI in some areas of the Global North, as compared to scientists in resource-limited regions, mostly in the Global South (Leonelli, 2016). Without enabling conditions ‘open access to data’ does not guarantee ‘fair access to data’. The inability to ‘‘self-use’’ DSI (Scholz et al., 2021) means that researchers in the Global South have less scientific agency over DSI and priority-setting in scientific research. This disparity between the ability to access and create benefits from data has led countries in the Global South to demand compensation for the use of DSI that originated from their region. Although many agree that it is fair to compensate and emancipate resource-limited but biodiversity rich countries (Bagley, 2016), the main issue is how to arrange this. At the Conference of the Parties (COP15) of the Convention on Biological Diversity (CBD) past December, Parties agreed to develop a multilateral benefit-sharing fund to which users of DSI would contribute. This fund would then be used to invest in biodiversity conservation and scientific capacity building in the Global South. However the question remains how to distribute the yield of such a multilateral fund? We argue that a fair distribution should at least take into account the different capabilities of scientists in different countries in generating and analysing data. In this paper we will focus mainly on academic scientists and engineers in various regions, leaving other actors such as indigenous peoples and companies out of the distribution picture for now. In developing principles for a fair distribution of benefits from DSI, we propose these three conditions: • The burden of execution shouldn’t be put solely on individual researchers and research organizations in the Global North, but they have a duty to contribute • Fair distribution of benefits should contribute to fair distribution of scientific agency • Fair distribution of access implies that management of data is restructured to reflect the needs of the Global South@en

Terwijl de natuur in rap tempo verloren gaat, ontstaat tegelijkertijd een wildgroei aan data afkomstig uit de natuur. Die data worden als gemeengoed gezien waarvan iedereen, waaronder natuurbeschermers, profiteert. Er ontstaan echter nieuwe vormen van digitale uitsluiting door ongelijkheden in onderzoekscapaciteiten, databeheer en datanormen met negatieve gevolgen voor internationale wetenschappelijke samenwerking en natuurbehoud. Producenten en gebruikers van data moeten daarom veel meer doen om de digitalisering van de natuur in juiste banen te leiden.@en

The recovery of resources, including water reuse, has been presented as a solution to overcome scarcity, and improve the economic and environmental performance of water provision and treatment. However, its implementation faces non-technical challenges, including the need to collaborate with new stakeholders and face societal acceptance issues. Looking at the prominence of the circular economy in current policy developments and the challenges to resource recovery, exploring these issues is urgently needed. In this work, we reviewed a broad range of literature to identify societal values relevant to the recovery of water and other resources from wastewaters, particularly urban and industrial wastewater and desalination brines. We discuss tensions and uncertainties around these values, such as the tension between socio-economic expectations of resource recovery and potential long-term sustainability impacts, as well as uncertainties regarding safety and regulations. For addressing these tensions and uncertainties, we suggest aligning common methods in engineering and the natural sciences with Responsible Innovation approaches, such as Value Sensitive Design and Safe-by-Design. To complement Responsible Innovation, social learning with a Sustainability Transitions or Adaptive Governance perspective is suggested.

@en

Emerging applications of biotechnology such as new genomic techniques may give rise to new uncertainties and uncertain risks. Particularly the increased complexity and limited knowledge of possible risks associated with these new
techniques, make it currently impossible to perform an adequate environmental risk assessment. As a result, there is a risk that such techniques don’t get beyond experiments demonstrating the proof of principle, stifling their further
development and implementation. To break free from this deadlock, wemust be able to learn what such uncertainties and uncertain risks entail, and how they should be assessed to ensure safe further development. To shape a responsible learning environment to explore uncertainties and uncertain risks, we have organized five stakeholder workshops. By means of a case about the genetic engineering of plants’ rhizosphere–an application abundant with uncertain risks–we identified tensions between different stakeholder groups and their different estimates of uncertainties and uncertain risks. Based upon derived insights, we developed a tool–a script for researchers to organize a
stakeholder workshop–that enables a constructive discussion about emerging risks with a broad range of stakeholders. Thereby, the script provides a step-by-step approach to identify uncertainties, develop anticipatory strategies and adaptations in (experimental) research designs to lower or mitigate the earlier
identified uncertainties, and helps to identify knowledge gaps for which (additional) risk research should be set up.@en

The increasing societal demand for safer, biobased products, and processes
creates opportunities for industrial biotechnology and chemistry. To succeed,
controlled learning about new emerging risks is crucial but both fields endure
difficulty in doing so by their respective regulation and risk management culture.@en

Genetic engineering techniques (e.g., CRISPR-Cas) have led to an increase in biotechnological developments, possibly leading to uncertain risks. The European Union aims to anticipate these by embedding the Precautionary Principle in its regulation for risk management. This principle revolves around taking preventive action in the face of uncertainty and provides guidelines to take precautionary measures when dealing with important values such as health or environmental safety. However, when dealing with ‘new’ technologies, it can be hard for risk managers to estimate the societal or environmental consequences of a biotechnology that might arise once introduced or embedded in society due to that these sometimes do not comply with the established norms within risk assessment. When there is insufficient knowledge, stakeholders active in early developmental stages (e.g., researchers) could provide necessary knowledge by conducting research specifically devoted to what these unknown risks could entail. In theory, the Safe-by-Design (SbD) approach could enable such a controlled learning environment to gradually identify what these uncertain risks are, to which we refer as responsible learning. In this paper, we argue that three conditions need to be present to enable such an environment: (1) regulatory flexibility, (2) co-responsibility between researchers and regulators, and (3) openness towards all stakeholders. If one of these conditions would not be present, the SbD approach cannot be implemented to its fullest potential, thereby limiting an environment for responsible learning and possibly leaving current policy behind to anticipate uncertain risks.@en

More pluralised understandings of incumbencies are often overlooked in transitions research, which may lead to underestimating the enabling roles of incumbents in niche projects. This study explores these roles by applying a power framework to five struggles revolving around a path-breaking decentralised wastewater treatment project in the city of Ghent (Belgium). Remarkably, incumbents from multiple regimes use power to enable the niche project. The study identifies and discusses four patterns in the enabling role of incumbents in niche projects. These patterns are clarified by focussing on incumbents from multiple regimes, belonging to local authorities, neighbouring and more distant regimes, as well as on the power of structural trends related to the urgency of sustainability challenges. As such, the study contributes to the understanding of multiple incumbencies and the conditions under which these may reinforce niche projects. For practitioners, the study underscores the role of power dynamics in the water/wastewater sector.

@en

Environmental problems are usually not tackled with path-departing policies but rather with incrementally adjusted or unchanged policies. One way to address incremental change is the policy feedback approach, which initially focussed on self-reinforcing feedback and path-dependency. Today, self-undermining feedback is also increasingly being studied, centring on agency and change. However, it is unclear precisely how actors use power in policy feedback processes. Therefore, this study applied a power perspective and the policy arrangement approach to a case study of the reorientation towards a circular economy in Dutch wastewater policy between 2008 and 2018, which resulted in incremental instead of fundamental policy change. Here it was observed that self-undermining feedback was generated from 2008 onwards but the balance quickly shifted back to self-reinforcing feedback, indicating that the analysed power struggles led to incremental change. These dynamics resemble a shift from the so-called paths and forks (i.e. fork in the road) towards the boomerang pattern (i.e. returning to its original position) of policy change. The patterns are explained by focussing on powerful actors that resist change through the use of incremental reforms, the ongoing struggles of these actors in facilitating self-reinforcing feedback and the role of interpretation in using feedback as a resource. Overall, this study provides a nuanced understanding of incremental change by directing attention to the power struggles of actors in policy feedback processes. For practitioners, the study emphasises the importance of power struggles in enabling a circular economy.

@en

In this paper, we provide an overview of how Safe-by-Design is conceived and applied in practice in a large number of engineering disciplines. We discuss the differences, commonalities, and possibilities for mutual learning found in those practices and identify several ways of putting those disciplinary outlooks in perspective. The considered engineering disciplines in the order of historically grown technologies are construction engineering, chemical engineering, aerospace engineering, urban engineering, software engineering, bio-engineering, nano-engineering, and finally cyber space engineering. Each discipline is briefly introduced, the technology at issue is described, the relevant or dominant hazards are examined, the social challenge(s) are observed, and the relevant developments in the field are described. Within each discipline the risk management strategies, the design principles promoting safety or safety awareness, and associated methods or tools are discussed. Possible dilemmas that the designers in the discipline face are highlighted. Each discipline is concluded by discussing the opportunities and bottlenecks in addressing safety. Commonalities and differences between the engineering disciplines are investigated, specifically on the design strategies for which empirical data have been collected. We argue that Safe-by-Design is best considered as a specific elaboration of Responsible Research and Innovation, with an explicit focus on safety in relation to other important values in engineering such as well-being, sustainability, equity, and affordability. Safe-by-Design provides for an intellectual venue where social science and the humanities (SSH) collaborate on technological developments and innovation by helping to proactively incorporate safety considerations into engineering practices, while navigating between the extremes of technological optimism and disproportionate precaution. As such, Safe-by-Design is also a practical tool for policymakers and risk assessors that helps shape governance arrangements for accommodating and incentivizing safety, while fully acknowledging uncertainty.

@en

Although both the Inherent Safety Principles (ISPs) and the Safe-by-Design (SbD) approach revolve around the central value of safety, they have a slightly different focus in terms of developing add-on features or considering initial design choices. This paper examines the differences between these approaches and analyses which approach is more suitable for a specific type of research—fundamental or applied. By applying the ISPs and SbD to a case study focusing on miniaturized processes using Hydrogen Cyanide, we find that both approaches encounter internal value-conflicts and suffer from external barriers, or lock-ins, which hinder implementation of safety measures. By applying the Technology Readiness Levels (TRLs), we gain insight in the matureness of a technology (thereby distinguishing fundamental and applied research) and the extent of lock-ins being present. We conclude that the ISPs are better able to deal with lock-ins, which are more common in applied research stages, as this approach provides guidelines for add-on safety measures. Fundamental research is not subject to lock-ins yet, and therefore SbD would be a more suitable approach. Lastly, application of either approach should not be associated with a specific field of interest, but instead with associated known or uncertain risks.@en

New technological developments such as CRISPR-Cas, advanced genetic sequencing and the digitalization of agriculture offer promising prospects to realize the potential of a sustainable bioeconomy. At the same time, enormous challenges abound such as the pressure on biodiversity and the associated risk of pandemics, climate change and the ever-increasing global economic inequality. The bioeconomy can play a beneficial role in this; however, this will only be possible if the bioeconomy is developed on the basis of inclusion. In this chapter I will explain the relevance of inclusion for the bioeconomy and describe some of the sociotechnical developments where inclusion should be realized in order to build a resilient and sustainable bioeconomy. These developments include biosphere capacity, global biobased value chains, digital genetic resources and the digitalization of agriculture. I will conclude with the question of who bears responsibility for an inclusive bioeconomy.@en

The term "responsibility" embodies many meanings, also in the context of corporate research and innovation (R&I). The approach of Responsible Research and Innovation (RRI) has emerged as a promoter for responsible conduct of innovation but so far lacks a systematic framework for describing, inventorying, and eventually managing different responsibilities that R&I units hold in companies and further in society. In this paper we take forward the idea of developing RRI into a "meta-responsibility" approach, for orchestrating responsibilities in corporate R&I. First, we introduce a frame for defining responsibility, which is inclusive of four elements (care, liability, accountability, and responsiveness), and is attentive to the intrinsic uncertainty of the R&I setting. Drawing on empirical data from interviews, we then examine how these responsibility elements become operationalised in an actual R&I project. As a result, we develop a meta-responsibility map for corporate R&I, bringing various and sometimes contradicting principles, expectations and obligations under the common terminology of responsibility. We suggest that such integrative outlook on responsibilities increases theoretical solidity and practical applicability of RRI as an innovation management approach. Regarding R&I practices, we conclude that the meta-responsibility map can support R&I units in exploring their co-existing and sometimes conflicting responsibilities, and in managing those responsibilities in the highly uncertain R&I setting. In particular, meta-responsibility shows applicability in (i) balancing risk and precaution, (ii) exposing and addressing concerns about the goals and impacts of innovation, and (iii) accelerating sectoral transition whilst securing one's own competitive advantage in it.

@en

Advanced gene editing techniques such as Clustered Regularly Interspaced Short Palindromic Repeat (CRISPR)/Cas have increased the pace of developments in the field of industrial biotechnology. Such techniques imply new possibilities when working with living organisms, possibly leading to uncertain risks. In the Netherlands, current policy fails to address these uncertain risks because risk classification is determined process‐wise (i.e., genetically modified organism [GMO] and non‐GMO), there is a strong focus on quantifiable risks, and the linearity within current governance (science–policy–society) hinders iterative communication between stakeholders, leaving limited room to anticipate uncertainties at an early stage of development. A suggested concept to overcome these shortcomings is the Safe‐by‐Design (SbD) approach, which, theoretically, allows stakeholders to iteratively incorporate safety measures throughout a technology's development process, creating a dynamic environment for the anticipation of uncertain risks. Although this concept originates from chemical engineering and is already widely applied in nanotechnology, for the field of biotechnology, there is no agreed upon definition yet. To explore the possibilities of SbD for future governance of biotechnology, we should gain insight in how various stakeholders perceive notions of risk, safety, and inherent safety, and what this implies for the applicability of SbD for risk governance concerning industrial biotechnology. Our empirical research reveals three main themes: (1) diverging expectations with regard to safety and risks, and to establish an acceptable level of risk; (2) different applications of SbD and inherent safety, namely, product‐ and process‐wise; and (3) unclarity in allocating responsibilities to stakeholders in the development process of a biotechnology and within society.@en

Biobased production has been promoted as a sustainable alternative to fossil resources. However, controversies over its impact on sustainability highlight societal concerns, value tensions and uncertainties that have not been taken into account during its development. In this work, the consideration of stakeholders’ values in a biorefinery design project is investigated. Value sensitive design (VSD) is a promising approach to the design of technologies with consideration of stakeholders’ values, however, it is not directly applicable for complex systems like biorefineries. Therefore, some elements of VSD, such as the identification of relevant values and their connection to a technology’s features, are brought into biorefinery design practice. Midstream modulation (MM), an approach to promoting the consideration of societal aspects during research and development activities, is applied to promote reflection and value considerations during the design decision making. As result, it is shown that MM interventions during the design process led to new design alternatives in support of stakeholders' values, and allowed to recognize and respond to emerging value tensions within the scope of the project. In this way, the present work shows a novel approach for the technical investigation of VSD, especially for biorefineries. Also, based on this work it is argued that not only reflection, but also flexibility and openness are important for the application of VSD in the context of biorefinery design.

@en

The growth in biofuels’ investment brings with it concerns about the social and environmental impacts of the sector. Several tools and frameworks have been used to address these concerns, including the Responsible Research and Innovation (RRI) framework. This paper analyzes whether this framework can be applied in contexts where local culture and values shape differently the freedom of speech and engagement, such as in developing countries in which biofuel innovation projects are often implemented. A literature review focused on eight case studies of other authors was used to explore the role of “participation” as a structural element of the RRI framework and the impact of its absence where effective participation in the innovation development process is not possible. In conclusion, we highlight how this inspirational normative framework, designed to influence innovation, is misused to judge its impacts. More than that, the conclusions of such misused applications reflect more the difficulties involved in applying guidelines than the responsible character of the innovation, whose impacts are usually defined upfront materially and measurably.

@en

There is now almost a decade of experience with RRI (Responsible Research and Innovation), including a growing emphasis on RRI in industry. Based on our experiences in the EU-funded project PRISMA, we find that the companies we engaged could be motivated to do RRI, but often only after we first shifted initial assumptions and strategies. Accordingly, we formulate six lessons we learned in the expectation that they will be relevant both for RRI in industry as well as for the future of RRI more broadly. These lessons are: (1) Strategize for stakeholder engagement; (2) Broaden current assessments; (3) Place values center stage; (4) Experiment for responsiveness; (5) Monitor RRI progress; and (6) Aim for shared value.

@en

Green and sustainable chemistry holds the promise of realising a sustainable society by providing environmentally friendly production processes. However until now the focus has been very much on reducing waste and hazards, while there is also a need to consider the broader societal impact of chemical innovations. This article presents three additional principles to guide those in green chemistry towards including social sustainability in innovation trajectories.

@en

Dit verslag geeft de bevindingen weer van een kortlopend onderzoek naar het gebruik van waterstofcyanide (HCN), ook wel Blauwzuur genaamd, in het veld van de (bio)chemie. In dit verslag worden de toxische eigenschappen van deze chemische stof afgewogen tegen veiligheidsaspecten vanuit het kader van Safe-by-Design gebruik makende van Inherent Safety Principles (ISPs).@en