Functionality-packed additively manufactured porous titanium implants

Journal article (2020)

Authors

I. A.J. van Hengel Biomaterials & Tissue Biomechanics - Mechanical, Maritime and Materials Engineering
I.A.J. van Hengel Biomaterials & Tissue Biomechanics - Mechanical, Maritime and Materials Engineering
Ingmar A.J. van Hengel Biomaterials & Tissue Biomechanics - Mechanical, Maritime and Materials Engineering
M. Minneboo Biomaterials & Tissue Biomechanics - Mechanical, Maritime and Materials Engineering
M.B. Minneboo Biomaterials & Tissue Biomechanics - Mechanical, Maritime and Materials Engineering
Harrie Weinans University Medical Center Utrecht, Biomaterials & Tissue Biomechanics - Mechanical, Maritime and Materials Engineering
HH Weinans University Medical Center Utrecht, Biomaterials & Tissue Biomechanics - Mechanical, Maritime and Materials Engineering
H. Weinans University Medical Center Utrecht, Biomaterials & Tissue Biomechanics - Mechanical, Maritime and Materials Engineering
Ad C. Fluit University Medical Center Utrecht
A. C. Fluit University Medical Center Utrecht
B. C.J. van der Eerden Erasmus Medical Centre
B.C.J. van der Eerden Erasmus Medical Centre
Lidy Fratila-Apachitei Biomaterials & Tissue Biomechanics - Mechanical, Maritime and Materials Engineering
Lidy E. Fratila-Apachitei Biomaterials & Tissue Biomechanics - Mechanical, Maritime and Materials Engineering
L. E. Fratila-Apachitei Biomaterials & Tissue Biomechanics - Mechanical, Maritime and Materials Engineering
E.L. Fratila-Apachitei Biomaterials & Tissue Biomechanics - Mechanical, Maritime and Materials Engineering
Julian Apachitei Biomaterials & Tissue Biomechanics - Mechanical, Maritime and Materials Engineering
I. Apachitei Biomaterials & Tissue Biomechanics - Mechanical, Maritime and Materials Engineering
A.A. Zadpoor Biomaterials & Tissue Biomechanics - Mechanical, Maritime and Materials Engineering
Amir Abbas Zadpoor Biomaterials & Tissue Biomechanics - Mechanical, Maritime and Materials Engineering
Amir A. Zadpoor Biomaterials & Tissue Biomechanics - Mechanical, Maritime and Materials Engineering
A. A. Zadpoor Biomaterials & Tissue Biomechanics - Mechanical, Maritime and Materials Engineering
Research Group
Biomaterials & Tissue Biomechanics (Mechanical, Maritime and Materials Engineering) (TU Delft)
Copyright: © 2020 I.A.J. van Hengel, F. S.A. Gelderman, S. Athanasiadis, M.B. Minneboo, Harrie Weinans, A. C. Fluit, B.C.J. van der Eerden, E.L. Fratila-Apachitei, I. Apachitei, A.A. Zadpoor
DOI: https://doi.org/10.1016/j.mtbio.2020.100060
More Info
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Published Date

2020

Language

English

Faculty

Mechanical, Maritime and Materials Engineering

Department

Biomechanical Engineering

Research Group

Biomaterials & Tissue Biomechanics

Abstract

The holy grail of orthopedic implant design is to ward off both aseptic and septic loosening for long enough that the implant outlives the patient. Questing this holy grail is feasible only if orthopedic biomaterials possess a long list of functionalities that enable them to discharge the onerous task of permanently replacing the native bone tissue. Here, we present a rationally designed and additive manufacturing (AM) topologically ordered porous metallic biomaterial that is made from Ti-6Al-4V using selective laser melting and packs most (if not all) of the required functionalities into a single implant. In addition to presenting a fully interconnected porous structure and form-freedom that enables realization of patient-specific implants, the biomaterials developed here were biofunctionalized using plasma electrolytic oxidation to locally release both osteogenic (i.e. strontium) and antibacterial (i.e. silver ions) agents. The same single-step biofunctionalization process also incorporated hydroxyapatite into the surface of the implants. Our measurements verified the continued release of both types of active agents up to 28 days. Assessment of the antibacterial activity in vitro and in an ex vivo murine model demonstrated extraordinarily high levels of bactericidal effects against a highly virulent and multidrug-resistant Staphylococcus aureus strain (i.e. USA300) with total eradication of both planktonic and adherent bacteria. This strong antibacterial behavior was combined with a significantly enhanced osteogenic behavior, as evidenced by significantly higher levels of alkaline phosphatase (ALP) activity compared with non-biofunctionalized implants. Finally, we discovered synergistic antibacterial behavior between strontium and silver ions, meaning that 4–32 folds lower concentrations of silver ions were required to achieve growth inhibition and total killing of bacteria. The functionality-packed biomaterial presented here demonstrates a unique combination of functionalities that make it an advanced prototype of future orthopedic biomaterials where implants will outlive patients.