The paper presents the initial outcomes of a project, currently ongoing under the supervision of the European Space Agency, having the main objective to specify and design a Fault Detection Isolation and Recovery (FDIR) system by making use of relevant RAMS (Reliability, Availability, Maintainability, Safety) analyses for missions in non-deterministic environment with limited resources. The initial project tasks have been to select a study case represented by a CubeSat complex mission, analyse in detail both its mission and system requirements and, based on them, define a set of relevant RAMS analyses to be carried out in the second phase of the project, as inputs for the development of a FDIR concept aimed at a careful balance of the limited spacecraft resources in case of critical failures. Two possible study cases have been identified: LUMIO, a 12U CubeSat mission for the observation of micro-meteoroid impacts on the Lunar farside, and M-ARGO, a 12U deep-space CubeSat which will rendezvous with a near-Earth asteroid and characterize its physical properties for the presence of in-situ resources. Although both missions are characterized by a high level of autonomy and complexity in a harsh environment, LUMIO has been eventually selected as study case for the project. In the paper, the challenges and features of this mission are shortly presented. The specificities of the RAMS analysis and FDIR concept for this specific class of small satellite missions (including the selected study case) are highlighted in the paper, looking in particular at aspects such as the improvement of reliability while maintaining the CubeSat philosophy, the tuning of mission and system requirements in view of facilitating the design and implementation of the FDIR concept, and the current gaps within the RAMS/FDIR body of knowledge. The conclusions drawn during this first project phase provide a real view of how systems engineering must work in tandem with RAMS analyses and FDIR to achieve a more robust and functional mission architecture, thus improving the mission reliability.

Objective: Neuroimaging studies show structural alterations of various brain regions in children and adults with attention deficit hyperactivity disorder (ADHD), although nonrepli-cations are frequent. The authors sought to identify cortical characteristics related to ADHD using large-scale studies. Methods: Cortical thickness and surface area (based on the Desikan–Killiany atlas) were compared between case subjects with ADHD (N=2,246) and control subjects (N=1,934) for children, adolescents, and adults separately in ENIGMA-ADHD, a consortium of 36 centers. To assess familial effects on cortical measures, case subjects, unaffected siblings, and control subjects in the NeuroIMAGE study (N=506) were compared. Associations of the attention scale from the Child Behavior Checklist with cortical measures were determined in a pediatric population sample (Generation-R, N=2,707). Results: In the ENIGMA-ADHD sample, lower surface area values were found in children with ADHD, mainly in frontal, cingulate, and temporal regions; the largest significant effect was for total surface area (Cohen’s d=20.21). Fusiform gyrus and temporal pole cortical thickness was also lower in children with ADHD. Neither surface area nor thickness differences were found in the adolescent or adult groups. Familial effects were seen for surface area in several regions. In an overlapping set of regions, surface area, but not thickness, was associated with attention problems in the Generation-R sample. Conclusions: Subtle differences in cortical surface area are widespread in children but not adolescents and adults with ADHD, confirming involvement of the frontal cortex and highlighting regions deserving further attention. Notably, the alterations behave like endophenotypes in families and are linked to ADHD symptoms in the population, extending evidence that ADHD behaves as a continuous trait in the population. Future longitudinal studies should clarify individual lifespan trajectories that lead to nonsignificant findings in adolescent and adult groups despite the presence of an ADHD diagnosis.