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J Staunton

10 records found

A polylinker approach to reductive loop swaps in modular polyketide synthases

Enantioselective synthesis of tetrasubstituted d-lactones.

Synthesis of Prelactone B

Knowledge-based design of bimodular and trimodular polyketide synthases based on domain and module swaps: a route to simple statin analogues

The thioesterase of the erythromycin-producing polyketide synthase: influence of acyl chain structure on the mode of release of substrate analogues from the acyl enzyme intermediates.

Enantiospecific synthesis of tetrasubstituted delta-lactones.

Evaluating precursor-directed biosynthesis towards novel erythromycins through in vitro studies on a biomodular polyketide synthase.

Engineering of a minimal modular polyketide synthase, and targeted alteration of the stereospecificity of polyketide chain extension.

Enantiospecific synthesis of analogues of the diketide intermediate of the erythromycin polyketide synthase (PKS).

Rational engineering of complex polyketide biosynthesis - Where do we begin?.