This paper proposes an automated approach to predict crack pattern similarities that correlate well with assessment by structural engineers. We use Siamese convolutional neural networks (SCNN) that take two crack pattern images as inputs and output scalar similarity measures. We focus on 2D masonry facades with and without openings. The image pairs are generated using a statistics-based approach and labelled by 28 structural engineering experts. When the data is randomly split into fit and test data, the SCNNs can achieve good performance on the test data ((Formula presented.)). When the SCNNs are tested on ”unseen” archetypes, their test (Formula presented.) values are on average 1% lower than the case where all archetypes are ”seen” during the training. These very good results indicate that SCNNs can generalise to unseen cases without compromising their performance. Although the analyses are restricted to the considered synthetic images, the results are promising and the approach is general.

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The degree of similarity between damage patterns often correlates with the likelihood of having similar damage causes. Therefore, deciding whether crack patterns are similar is one of the key steps in assessing the conditions of masonry structures. To our knowledge, no literature has been published regarding masonry crack pattern similarity measures that would correlate well with assessment by structural engineers. Hence, currently, similarity assessments are solely performed by experts and require considerable time and effort. Moreover, it is expensive, limited by the availability of experts, and yields only qualitative answers. In this work, we propose an automated approach that has the potential to overcome the above shortcomings and perform comparably with experts. At its core is a deep neural network embedding that can be used to calculate a numerical distance between crack patterns on comparable façades. The embedding is obtained from fitting a deep neural network to perform a classification task; i.e., to predict the crack pattern archetype label from a crack pattern image. The network is fitted to synthetic crack patterns simulated using a statistics-based approach proposed in this work. The simulation process can account for important crack pattern characteristics such as crack location, orientation, and length. The embedding transforms a crack pattern (raster image) into a 64-dimensional real-valued vector space where the closeness between two vectors is calculated as the cosine of their angle. The proposed approach is tested on 2D façades with and without openings, and with synthetic crack patterns that consist of a single crack and multiple cracks.@en

Background: Identifying persons at risk for cognitive decline may aid in early detection of persons at risk of dementia and to select those that would benefit most from therapeutic or preventive measures for dementia. Objective: In this study we aimed to validate whether cognitive decline in the general population can be predicted with multivariate data using a previously proposed supervised classification method: Disease State Index (DSI). Methods: We included 2,542 participants, non-demented and without mild cognitive impairment at baseline, from the population-based Rotterdam Study (mean age 60.9 ± 9.1 years). Participants with significant global cognitive decline were defined as the 5% of participants with the largest cognitive decline per year. We trained DSI to predict occurrence of significant global cognitive decline using a large variety of baseline features, including magnetic resonance imaging (MRI) features, cardiovascular risk factors, APOE-ε4 allele carriership, gait features, education, and baseline cognitive function as predictors. The prediction performance was assessed as area under the receiver operating characteristic curve (AUC), using 500 repetitions of 2-fold cross-validation experiments, in which (a randomly selected) half of the data was used for training and the other half for testing. Results: A mean AUC (95% confidence interval) for DSI prediction was 0.78 (0.77–0.79) using only age as input feature. When using all available features, a mean AUC of 0.77 (0.75–0.78) was obtained. Without age, and with age-corrected features and feature selection on MRI features, a mean AUC of 0.70 (0.63–0.76) was obtained, showing the potential of other features besides age. Conclusion: The best performance in the prediction of global cognitive decline in the general population by DSI was obtained using only age as input feature. Other features showed potential, but did not improve prediction. Future studies should evaluate whether the performance could be improved by new features, e.g., longitudinal features, and other prediction methods.

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Multichannel image registration is an important challenge in medical image analysis. Multichannel images result from modalities such as dual-energy CT or multispectral microscopy. Besides, multichannel feature images can be derived from acquired images, for instance, by applying multiscale feature banks to the original images to register. Multichannel registration techniques have been proposed, but most of them are applicable to only two multichannel images at a time. In the present study, we propose to formulate multichannel registration as a groupwise image registration problem. In this way, we derive a method that allows the registration of two or more multichannel images in a fully symmetric manner (i.e., all images play the same role in the registration procedure), and therefore, has transitive consistency by definition. The method that we introduce is applicable to any number of multichannel images, any number of channels per image, and it allows to take into account correlation between any pair of images and not just corresponding channels. In addition, it is fully modular in terms of dissimilarity measure, transformation model, regularisation method, and optimisation strategy. For two multimodal datasets, we computed feature images from the initially acquired images, and applied the proposed registration technique to the newly created sets of multichannel images. MIND descriptors were used as feature images, and we chose total correlation as groupwise dissimilarity measure. Results show that groupwise multichannel image registration is a competitive alternative to the pairwise multichannel scheme, in terms of registration accuracy and insensitivity towards registration reference spaces.

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White matter lesions play a role in cognitive decline and dementia. One presumed pathway is through disconnection of functional networks. Little is known about location-specific effects of lesions on functional connectivity. This study examined location-specific effects within anatomically-defined white matter tracts in 1584 participants of the Rotterdam Study, aged 50–95. Tracts were delineated from diffusion magnetic resonance images using probabilistic tractography. Lesions were segmented on fluid-attenuated inversion recovery images. Functional connectivity was defined across each tract on resting-state functional magnetic resonance images by using gray matter parcellations corresponding to the tract ends and calculating the correlation of the mean functional activity between the gray matter regions. A significant relationship between both local and brain-wide lesion load and tract-specific functional connectivity was found in several tracts using linear regressions, also after Bonferroni correction. Indirect connectivity analyses revealed that tract-specific functional connectivity is affected by lesions in several tracts simultaneously. These results suggest that local white matter lesions can decrease tract-specific functional connectivity, both in direct and indirect connections.

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