This research provides a performance measurement framework for Reverse Innovation (RI) within the healthcare sector. In order to design this performance measurement framework, literature analysis was combined with data from current practices that was obtained by interviewing product managers from multination companies (MNCs) in the healthcare sector that have produced RIs. Within the performance measurement framework four categories are used: financial performance, product innovation performance, sustainability performance and customer satisfaction performance. This performance measurement framework can be used to assess the performance of RIs and MNCs pursuing RIs which can help managers in their decision making and daily business management.