Offshore wind farms are a promising source of renewable energy, but they face significant challenges in terms of operation and maintenance (O&M). Traditional scheduling models often overlook the potential of condition-based maintenance (CBM). Addressing this gap, this paper introduces a novel framework, incorporating principles of Model Predictive Control (MPC), to optimize the O&M scheduling of offshore wind farms using prognostic-driven maintenance. The framework integrates probabilistic remaining useful life (RUL) prognosis in a mixed-integer linear programming (MILP) optimization model with a rolling horizon approach, in alignment with MPC’s predictive and adaptive decision-making approach. The optimization model determines the optimal time to replace each component by minimizing the expected cost over the expected lifetime. This approach seeks to achieve the lowest expense while guaranteeing the highest utilization rate of each component. For the case study presented, the total O&M costs are reduced by up to 15% with respect to corrective maintenance strategies.@en