The simulation of long life behavior and environmental aging effects on composite materials are subjects of investigation for future aerospace applications (i.e. supersonic commercial aircrafts). Temperature variation in addition to matrix oxidation involves material degradation and loss of mechanical properties. Crack initiation and growth is the main damage mechanism. In this paper, an extended finite element analysis is proposed to simulate damage on carbon fiber reinforced polymer as a consequence of thermal fatigue between −50℃ and 150℃ under atmospheres with different oxygen content. The interphase effect on the degradation process is analyzed at a microscale level. Finally, results are correlated with the experimental data in terms of material stiffness and, hence, the most suitable model parameters are selected.