In Phantom Validation of Time-Domain Near-Infrared Optical Tomography Pioneer for Imaging Brain Hypoxia and Hemorrhage

Book chapter (2021)

Authors

Junyi Jiang University Hospital Zürich, University of Zürich
S. Lindner University of Zürich, University Hospital Zürich, Swiss Federal Institute of Technology
A. Di Costanzo-Mata University Hospital Zürich, University of Zürich
C. Zhang EKL Equipment - EEMCS
E. Charbon-Iwasaki-Charbon Quantum Circuit Architectures and Technology - EEMCS , Swiss Federal Institute of Technology, , (OLD)Applied Quantum Architectures
M. Wolf University of Zürich, University Hospital Zürich
A. Kalyanov University of Zürich, University Hospital Zürich
Research Group
EKL Equipment (EEMCS) (TU Delft)
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Published Date

2021

Language

English

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Faculty

Electrical Engineering, Mathematics and Computer Science

Department

Else Kooi Laboratory

Research Group

EKL Equipment

Abstract

The neonatal brain is a vulnerable organ, and lesions due to hemorrhage and/or ischemia occur frequently in preterm neonates. Even though neuroprotective therapies exist, there is no tool available to detect the ischemic lesions. To address this problem, we have recently designed and built the new time-domain near-infrared optical tomography (TD NIROT) system – Pioneer. Here we present the results of a phantom study of the system performance. We used silicone phantoms to mimic risky situations for brain lesions: hemorrhage and hypoxia. Employing Pioneer, we were able to reconstruct accurately both position and optical properties of these inhomogeneities.

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