Automated Epilepsy Diagnosis beyond IEDs by Multimodal Features and Deep Learning

Abstract

Automated diagnosis of epilepsy for differentiating epileptic EEGs without Interictal Epileptic Discharges (IEDs) from normal EEGs remains a critical challenge in clinical settings.
Current state-of-the-art methods use algorithms that can effectively detect epilepsy seizures which improves the current treatment methods for people suffer from epilepsy. Electroencephalograms (EEGs) analyzed by neurologists which are not able to meet the criteria are further looked into to obtain an efficient classification. This thesis presents an automated epilepsy diagnosis approach using a multi-algorithmic feature extraction pipeline. The final models include the development of a robust multi-processing feature extraction pipeline, the application of advanced machine learning / deep learning algorithms, and the validation of the proposed methods on comprehensive EEG datasets. The results, achieved using an XGBoost classifier with leave-one-subject-out (LOSO) cross-validation, demonstrate comparable performance to state-of-the-art epilepsy detectors. The study emphasizes the detection of epilepsy without IEDs, optimizing models through nested cross-validation, and evaluates their performance on the Temple University Hospital (TUH) and Erasmus Medical Center (EMC) Rotterdam datasets.