A highly sensitive capacitive displacement sensor for force measurement integrated in an engineered heart tissue platform

Conference paper (2023)

Authors

M. Dostanic Leiden University Medical Center, Electronic Components, Technology and Materials - EEMCS
F. Pfaiffer Student
Mahdieh Shojaei Baghini University of Glasgow
Laura Windt Leiden University Medical Center
Maury Wiendels Leiden University Medical Center
M. Wiendels Leiden University Medical Center
Maury Wiendels Leiden University Medical Center
M. Wiendels Leiden University Medical Center
Berend van Meer Leiden University Medical Center
Berend J. van Meer Leiden University Medical Center
C. L. Mummery Leiden University Medical Center, University of Twente
Pasqualina M. Sarro Electronic Components, Technology and Materials - EEMCS
Pasqualina M Sarro Electronic Components, Technology and Materials - EEMCS
Massimo Mastrangeli Electronic Components, Technology and Materials - EEMCS
Research Group
Electronic Components, Technology and Materials (EEMCS) (TU Delft)
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Published Date

2023

Language

English

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Faculty

Electrical Engineering, Mathematics and Computer Science

Department

Microelectronics

Research Group

Electronic Components, Technology and Materials

Abstract

We present a novel capacitive displacement sensor integrated in an engineered heart tissue (EHT) platform to measure tissue contractile properties in-situ. Co-planar spiral capacitors were integrated into the elastomeric substrate underneath the two micropillars of a previously developed EHT platform. The capacitor plates are displaced by the tension and compression that occurs in the substrate when the micropillars bend under contractile tissue force. For a contraction force of ~200 µN, applied in the middle of pillar length, the expected change in base capacitance is in the aF range. Readout of such low capacitance changes was achieved using a commercial low-noise high-sensitivity device. Characterization of static and dynamic sensor behavior agreed with numerical simulations, demonstrating a responsivity of 0.35 ± 0.07 fF/µN. Preliminary tests with cardiac tissues proved biocompatibility of the platform, as EHTs successfully formed and remained functional for at least 14 days

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