In vitro degradation and surface bioactivity of iron-matrix composites containing silicate-based bioceramic

Journal article (2017)

Authors

S. Wang Chinese Academy of Sciences, Shanghai Institute of Technology
Y Xu Shanghai Jiao Tong University
J. Zhou Biomaterials & Tissue Biomechanics - Mechanical, Maritime and Materials Engineering
H. Li Shanghai Jiao Tong University
Jiang Chang Chinese Academy of Sciences
Z. Huan Chinese Academy of Sciences
Research Group
Biomaterials & Tissue Biomechanics (Mechanical, Maritime and Materials Engineering) (TU Delft)
Copyright: © 2017 S. Wang, Y. Xu, J. Zhou, H. Li, Jiang Chang, Z. Huan
DOI: https://doi.org/10.1016/j.bioactmat.2016.12.001
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Published Date

2017

Language

English

Faculty

Mechanical, Maritime and Materials Engineering

Department

Biomechanical Engineering

Research Group

Biomaterials & Tissue Biomechanics

Abstract

Iron-matrix composites with calcium silicate (CS) bioceramic as the reinforcing phase were fabricated through powder metallurgy processes. The microstructures, mechanical properties, apatite deposition and biodegradation behavior of the Fe-CS composites, as well as cell attachment and proliferation on
their surfaces, were characterized. In the range of CS weight percentages selected in this study, the composites possessed compact structures and showed differently decreased bending strengths as compared with pure iron. Immersion tests in simulated body fluid (SBF) revealed substantially enhanced deposition of CaP on the surfaces of the composites as well as enhanced degradation rates as compared with pure iron. In addition, the composite containing 20% CS showed a superior ability to stimulate hBMSCs proliferation when compared to pure iron. Our results suggest that incorporating calcium silicate particles into iron could be an effective approach to developing iron-based biodegradable bone implants with improved biomedical performance.