4D Printing for Biomedical Applications

Review (2024)

Authors

E. Yarali Biomaterials & Tissue Biomechanics - Mechanical, Maritime and Materials Engineering
Ebrahim Yarali Biomaterials & Tissue Biomechanics - Mechanical, Maritime and Materials Engineering
Mohammad Javad Mirzaali Biomaterials & Tissue Biomechanics - Mechanical, Maritime and Materials Engineering
Mohammad J. Mirzaali Biomaterials & Tissue Biomechanics - Mechanical, Maritime and Materials Engineering
Ava Ghalayaniesfahani Emerging Materials - IDE , Biomaterials & Tissue Biomechanics - Mechanical, Maritime and Materials Engineering
A. Ghalayaniesfahani Emerging Materials - IDE , Biomaterials & Tissue Biomechanics - Mechanical, Maritime and Materials Engineering
A. Accardo Micro and Nano Engineering - Mechanical, Maritime and Materials Engineering
Angelo Accardo Micro and Nano Engineering - Mechanical, Maritime and Materials Engineering
P.J. Diaz-Payno Biomaterials & Tissue Biomechanics - Mechanical, Maritime and Materials Engineering , Erasmus Medical Centre
Pedro J. Diaz-Payno Biomaterials & Tissue Biomechanics - Mechanical, Maritime and Materials Engineering , Erasmus Medical Centre
Pedro J. Diaz Payno Biomaterials & Tissue Biomechanics - Mechanical, Maritime and Materials Engineering , Erasmus Medical Centre
P.J. Diaz Payno Biomaterials & Tissue Biomechanics - Mechanical, Maritime and Materials Engineering , Erasmus Medical Centre
Amir Abbas Zadpoor Biomaterials & Tissue Biomechanics - Mechanical, Maritime and Materials Engineering
Amir A. Zadpoor Biomaterials & Tissue Biomechanics - Mechanical, Maritime and Materials Engineering
A. A. Zadpoor Biomaterials & Tissue Biomechanics - Mechanical, Maritime and Materials Engineering
A.A. Zadpoor Biomaterials & Tissue Biomechanics - Mechanical, Maritime and Materials Engineering
Research Group
Biomaterials & Tissue Biomechanics (Mechanical, Maritime and Materials Engineering) (TU Delft)
More Info
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Published Date

2024

Language

English

Faculty

Mechanical, Maritime and Materials Engineering

Department

Biomechanical Engineering

Research Group

Biomaterials & Tissue Biomechanics

Abstract

4D (bio-)printing endows 3D printed (bio-)materials with multiple functionalities and dynamic properties. 4D printed materials have been recently used in biomedical engineering for the design and fabrication of biomedical devices, such as stents, occluders, microneedles, smart 3D-cell engineered microenvironments, drug delivery systems, wound closures, and implantable medical devices. However, the success of 4D printing relies on the rational design of 4D printed objects, the selection of smart materials, and the availability of appropriate types of external (multi-)stimuli. Here, this work first highlights the different types of smart materials, external stimuli, and design strategies used in 4D (bio-)printing. Then, it presents a critical review of the biomedical applications of 4D printing and discusses the future directions of biomedical research in this exciting area, including in vivo tissue regeneration studies, the implementation of multiple materials with reversible shape memory behaviors, the creation of fast shape-transformation responses, the ability to operate at the microscale, untethered activation and control, and the application of (machine learning-based) modeling approaches to predict the structure–property and design–shape transformation relationships of 4D (bio)printed constructs.