Why Argonaute is needed to make microRNA target search fast and reliable

Journal article (2017)

Authors

M. Klein Kavli institute of nanoscience Delft, BN/Martin Depken Lab - AS
S.D. Chandradoss BN/Chirlmin Joo Lab - AS , Kavli institute of nanoscience Delft
S.M. Depken BN/Martin Depken Lab - AS , Kavli institute of nanoscience Delft
C. Joo BN/Chirlmin Joo Lab - AS , Kavli institute of nanoscience Delft
Research Group
BN/Martin Depken Lab (AS) (TU Delft)
Copyright: © 2017 M. Klein, S.D. Chandradoss, S.M. Depken, C. Joo
DOI: https://doi.org/10.1016/j.semcdb.2016.05.017
More Info
expand_more

Published Date

2017

Language

English

Reuse Rights

Other than for strictly personal use, it is not permitted to download, forward or distribute the text or part of it, without the consent of the author(s) and/or copyright holder(s), unless the work is under an open content license such as Creative Commons.

Faculty

Applied Sciences

Department

BN/Bionanoscience

Research Group

BN/Martin Depken Lab

Abstract

MicroRNA (miRNA) interferes with the translation of cognate messenger RNA (mRNA) by finding, preferentially binding, and marking it for degradation. To facilitate the search process, Argonaute (Ago) proteins come together with miRNA, forming a dynamic search complex. In this review we use the language of free-energy landscapes to discuss recent single-molecule and high-resolution structural data in the light of theoretical work appropriated from the study of transcription-factor search. We suggest that experimentally observed internal states of the Ago-miRNA search complex may have the explicit biological function of speeding up search while maintaining specificity.

Files

Klein_et_all.pdf
(pdf | 2.83 Mb)
Unknown license

Download not available

1_s2.0_S1084952116301434_main.... (pdf)
(pdf | 2.2 Mb)
help_outline