New type of basket stationary bed reactor for heterogeneous biocatalysis

Journal article (2023)

Authors

Dominika Stradomska Silesian University of Technology
Daria Świętochowska Silesian University of Technology
Robert Kubica Silesian University of Technology
U. Hanefeld BT/Biocatalysis - AS
Ulf Hanefeld BT/Biocatalysis - AS
K. Szymańska Silesian University of Technology
Katarzyna Szymańska Silesian University of Technology
Research Group
BT/Biocatalysis (AS) (TU Delft)
Copyright: © 2023 Dominika Stradomska, Daria Świętochowska, Robert Kubica, U. Hanefeld, Katarzyna Szymańska
DOI: https://doi.org/10.1016/j.cep.2023.109590
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Published Date

2023

Language

English

Reuse Rights

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Faculty

Applied Sciences

Department

BT/Biotechnologie

Research Group

BT/Biocatalysis

Abstract

Effectiveness of catalytic processes using heterogeneous biocatalysts depends not only on the activity of the enzyme, but also on the efficiency of the used reactor. In this paper, we present a novel design of a basket reactor with a stationary catalyst bed (StatBioChem). The developed design was compared to a commercially available rotating bed reactor (SpinChem®). The biocatalysts used were invertase and acyltransferase from Mycobacterium smegmatis (MsAcT) immobilised on macroporous silica supports. The obtained values of initial reaction rate, both in the reaction of saccharose hydrolysis and 2,2-dimethyl-1,3-propanediol (NPG) transesterification, were twice higher for the StatBioChem reactor. A similar relationship was also observed regarding the process efficiency expressed as STY.

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