Influence of laser parameters and experimental conditions on nonphotochemical laser-induced nucleation of glycine polymorphs

Journal article (2021)

Authors

D. Irimia Intensified Reaction and Separation Systems - Mechanical, Maritime and Materials Engineering , Complex Fluid Processing - Mechanical, Maritime and Materials Engineering
J. Jose Shirley ChemE/Delft Ingenious Design - AS
A.E.D.M. van der Heijden Intensified Reaction and Separation Systems - Mechanical, Maritime and Materials Engineering , Complex Fluid Processing - Mechanical, Maritime and Materials Engineering
H.J.M. Kramer Complex Fluid Processing - Mechanical, Maritime and Materials Engineering , Intensified Reaction and Separation Systems - Mechanical, Maritime and Materials Engineering
H.B. Eral Intensified Reaction and Separation Systems - Mechanical, Maritime and Materials Engineering , Complex Fluid Processing - Mechanical, Maritime and Materials Engineering
Research Group
Complex Fluid Processing (Mechanical, Maritime and Materials Engineering) (TU Delft)
Copyright: © 2021 D. Irimia, J. Jose Shirley, Anshul S. Garg, Davey P.A. Nijland, A.E.D.M. van der Heijden, H.J.M. Kramer, H.B. Eral
DOI: https://doi.org/10.1021/acs.cgd.0c01415
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Published Date

2021

Language

English

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Faculty

Mechanical, Maritime and Materials Engineering

Department

Process and Energy

Research Group

Complex Fluid Processing

Abstract

Nonphotochemical laser-induced nucleation (NPLIN) is a promising primary nucleation control method, yet its underlying mechanism remains elusive. To contribute to the discussion on whether the polarization of laser irradiation in NPLIN experiments influences the polymorphic outcome, we revisit NPLIN experiments with aqueous glycine solutions with supersaturations ranging between S = 1.5 and S = 1.7 irradiated by nanosecond pulses (∼7 ns) of near-infrared wavelength (1064 nm). Systematically altering laser light excitation properties, including the number of pulses and type of polarization, we quantified the nucleation kinetics and characterized the polymorphic form that crystallized upon laser irradiation. Due to the stochasticity of the nucleation process, a large number of samples (>100 per each experimental point) were studied under carefully controlled experimental conditions such as the ambient temperature, cooling rate, and aging period. We observed significant differences among laser-irradiated, spontaneously nucleated, and crash-cooled samples in terms of nucleation kinetics and polymorphic form. This result indicates that laser irradiation provides a different polymorph-forming pathway in comparison to crash-cooling and spontaneous nucleation. However, no clear dependence between the polymorphic form and the polarization of laser irradiation is observed. We discuss our results in the context of previous reports supported thorough quantification of sample heating in NPLIN experiments.

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