Natural Deep Eutectic Solvents as Performance Additives for Peroxygenase Catalysis

Journal article (2019)

Authors

Yunjian Ma South China University of Technology
Yongru Li South China University of Technology
Shahid Ali South China University of Technology
Peilin Li South China University of Technology
W. Zhang BT/Biocatalysis - AS
M.C.R. Rauch BT/Biocatalysis - AS
S.J. Willot BT/Biocatalysis - AS
Doris Ribitsch acib GmbH
Frank Hollmann BT/Biocatalysis - AS
F. Hollmann BT/Biocatalysis - AS
More Authors... External organisation
Research Group
BT/Biocatalysis (AS) (TU Delft)
Copyright: © 2019 Yunjian Ma, Yongru Li, Shahid Ali, Peilin Li, W. Zhang, M.C.R. Rauch, S.J. Willot, Doris Ribitsch, F. Hollmann, More Authors
DOI: https://doi.org/10.1002/cctc.201901842
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Published Date

2019

Language

English

Faculty

Applied Sciences

Department

BT/Biotechnologie

Research Group

BT/Biocatalysis

Abstract

Natural deep eutectic solvents (NADES) are proposed as alternative solvents for peroxygenase-catalysed oxyfunctionalization reactions. Choline chloride-based NADES are of particular interest as they can serve as solvent, enzyme-stabiliser and sacrificial electron donor for the in situ H2O2 generation. This report provides the first proof-of-concept and basic characterisation of this new reaction system. Highly promising turnover numbers for the biocatalysts of up to 200,000 have been achieved.