Design and functional testing of a novel blood pulse wave velocity sensor

Journal article (2018)

Authors

M.H.N. van Velzen Erasmus Medical Centre
Marit H.N. van Velzen Erasmus Medical Centre
Arjo J. Loeve Medical Instruments & Bio-Inspired Technology - Mechanical, Maritime and Materials Engineering
A.J. Loeve Medical Instruments & Bio-Inspired Technology - Mechanical, Maritime and Materials Engineering
Bert Mik Erasmus Medical Centre
E.G. Mik Erasmus Medical Centre
Egbert G. Mik Erasmus Medical Centre
Sjoerd P. Niehof Erasmus Medical Centre
S.P. Niehof Erasmus Medical Centre
Research Group
Medical Instruments & Bio-Inspired Technology (Mechanical, Maritime and Materials Engineering) (TU Delft)
Copyright: © 2018 M.H.N. van Velzen, A.J. Loeve, E.G. Mik, S.P. Niehof
DOI: https://doi.org/10.1115/1.4038308
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Published Date

2018

Language

English

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Faculty

Mechanical, Maritime and Materials Engineering

Department

Biomechanical Engineering

Research Group

Medical Instruments & Bio-Inspired Technology

Abstract

The multiphotodiode array (MPA) is a novel transmission photoplethysmography (PPG) sensor to measure pulse wave velocity (PWV) in the finger. To validate the MPA, a setup was built to generate a red laser dot traveling over the MPA with known and constant scanning velocities. These scanning velocities were chosen to include speeds at least twice as high as those found in the normal range of PWV in healthy populations and were set at 12.9, 25.8, 36, or 46.7 m/s. The aim of this study was to verify the functionality of the MPA: performing local noninvasive PWV measurements. To illustrate the applicability of the MPA in clinical practice, an in vivo pilot study was conducted using the flow-mediated dilation (FMD) technique. The in vitro accuracy of the MPA was ±0.2%, 0.3%, 0.5%, and 0.6% at the applied scanning velocities. The MPA can measure PWVs with a maximum deviation of 3.0%. The in vivo pilot study showed a PWV before the FMD of 1.1±0.2 m/s. These results suggest that this novel MPA can reliably and accurately measure PWV within clinically relevant ranges and even well beyond.

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