Health-Related Quality of Life of Bone and Soft-Tissue Tumor Patients around the Time of Diagnosis

Journal article (2023)

Authors

Anouk A. Kruiswijk Leiden University Medical Center
Desiree M.J. Dorleijn University Hospital Ghent
P. J. Marang-Van De Mheen Leiden University Medical Center
P.J. Marang-van de Mheen Leiden University Medical Center
Perla J. Marang-van de Mheen Leiden University Medical Center
P.J. Marang-van De Mheen Leiden University Medical Center
P.J. Marang-Van De Mheen Leiden University Medical Center
P. J. Marang-van De Mheen Leiden University Medical Center
Perla J. Marang-van De Mheen Leiden University Medical Center
P. J. Marang-van de Mheen Leiden University Medical Center
Perla J. Marang-Van De Mheen Leiden University Medical Center
Michiel A.J. van de Sande Leiden University Medical Center
Leti van Bodegom-Vos Leiden University Medical Center
Leti Van Bodegom-Vos Leiden University Medical Center
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Published Date

2023

Language

English

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Abstract

Background: Bone and soft-tissue tumor patients experience long-lasting physical and psychological challenges. It is unknown to what extent Health-Related Quality of Life (HRQoL) is already affected during the diagnostic process. This study assesses the HRQoL of bone and soft-tissue tumor patients around time of diagnosis and explores which patient or tumor characteristics are associated with a reduced HRQoL. Methods: All patients with a suspected benign/malignant bone tumor (BT), benign soft-tissue tumor (STT), or malignant soft-tissue sarcoma (STS) visiting the Leiden University Medical Center between 2016 and 2020 were invited to complete the Patient-Reported Outcomes Measurement Information System (PROMIS) 29-item profile questionnaire. Mean scores of all included patients and per diagnosis group were compared to mean scores of the general population using one-sample t-tests. Results: Overall, patients (n = 637) reported statistically significantly worse HRQoL-scores on anxiety (51.3 ± 9.6), pain (55.3 ± 10.1), physical functioning (46.0 ± 9.7), and social functioning (48.1 ± 10.8) with the difference in pain and physical functioning being clinically relevant (based on a 3-point difference on t-metric). HRQoL-scores differed between diagnosis subgroups, i.e., patients with malignant tumors had higher anxiety levels and experienced more pain, where patients with bone tumors had worse physical functioning. Conclusion: The HRQoL of patients with suspected bone and soft-tissue tumors is already affected during the diagnostic process.