Rational positioning of 3D-printed voxels to realize high-fidelity multifunctional soft-hard interfaces

Journal article (2023)

Authors

M. Saldívar Biomaterials & Tissue Biomechanics - Mechanical, Maritime and Materials Engineering
Mauricio Cruz Saldívar Biomaterials & Tissue Biomechanics - Mechanical, Maritime and Materials Engineering
Mauricio Cruz Cruz Saldivar Biomaterials & Tissue Biomechanics - Mechanical, Maritime and Materials Engineering
M. Cruz Saldivar Biomaterials & Tissue Biomechanics - Mechanical, Maritime and Materials Engineering
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Edwin Tay Biomaterials & Tissue Biomechanics - Mechanical, Maritime and Materials Engineering
E.T.W.S. Tay Biomaterials & Tissue Biomechanics - Mechanical, Maritime and Materials Engineering
M. Fenu BN/Gijsje Koenderink Lab , Erasmus Medical Centre
Michele Fenu BN/Gijsje Koenderink Lab , Erasmus Medical Centre
Maria Klimopoulou Biomaterials & Tissue Biomechanics - Mechanical, Maritime and Materials Engineering
M. Klimopoulou Biomaterials & Tissue Biomechanics - Mechanical, Maritime and Materials Engineering
Gerjo Van Osch Erasmus Medical Centre, Biomaterials & Tissue Biomechanics - Mechanical, Maritime and Materials Engineering
G.J.V.M. Van Osch Erasmus Medical Centre, Biomaterials & Tissue Biomechanics - Mechanical, Maritime and Materials Engineering
Gerjo J.V.M. van Osch Erasmus Medical Centre, Biomaterials & Tissue Biomechanics - Mechanical, Maritime and Materials Engineering
G.J.V.M. van Osch Erasmus Medical Centre, Biomaterials & Tissue Biomechanics - Mechanical, Maritime and Materials Engineering
Gerjo J.V.M. Van Osch Erasmus Medical Centre, Biomaterials & Tissue Biomechanics - Mechanical, Maritime and Materials Engineering
Gerjo van Osch Erasmus Medical Centre, Biomaterials & Tissue Biomechanics - Mechanical, Maritime and Materials Engineering
L. E. Fratila-Apachitei Biomaterials & Tissue Biomechanics - Mechanical, Maritime and Materials Engineering
E.L. Fratila-Apachitei Biomaterials & Tissue Biomechanics - Mechanical, Maritime and Materials Engineering
Lidy Fratila-Apachitei Biomaterials & Tissue Biomechanics - Mechanical, Maritime and Materials Engineering
Lidy E. Fratila-Apachitei Biomaterials & Tissue Biomechanics - Mechanical, Maritime and Materials Engineering
E.L. Doubrovski Mechatronic Design - IDE
Zjenja Doubrovski Mechatronic Design - IDE
Mohammad J. Mirzaali Biomaterials & Tissue Biomechanics - Mechanical, Maritime and Materials Engineering
Mohammad Javad Mirzaali Biomaterials & Tissue Biomechanics - Mechanical, Maritime and Materials Engineering
Amir Abbas Zadpoor Biomaterials & Tissue Biomechanics - Mechanical, Maritime and Materials Engineering
A. A. Zadpoor Biomaterials & Tissue Biomechanics - Mechanical, Maritime and Materials Engineering
A.A. Zadpoor Biomaterials & Tissue Biomechanics - Mechanical, Maritime and Materials Engineering
Amir A. Zadpoor Biomaterials & Tissue Biomechanics - Mechanical, Maritime and Materials Engineering
Research Group
Biomaterials & Tissue Biomechanics (Mechanical, Maritime and Materials Engineering) (TU Delft)
Copyright: © 2023 M. Cruz Saldivar, Robin Petrus Elias Veeger, E.T.W.S. Tay, M. Fenu, M. Klimopoulou, G.J.V.M. van Osch, E.L. Fratila-Apachitei, E.L. Doubrovski, Mohammad J. Mirzaali, A.A. Zadpoor, More Authors
DOI: https://doi.org/10.1016/j.xcrp.2023.101552
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Published Date

2023

Language

English

Faculty

Mechanical, Maritime and Materials Engineering

Department

Biomechanical Engineering

Research Group

Biomaterials & Tissue Biomechanics

Abstract

Living organisms use functional gradients (FGs) to interface hard and soft materials (e.g., bone and tendon), a strategy with engineering potential. Past attempts involving hard (or soft) phase ratio variation have led to mechanical property inaccuracies because of microscale-material macroscale-property nonlinearity. This study examines 3D-printed voxels from either hard or soft phase to decode this relationship. Combining micro/macroscale experiments and finite element simulations, a power law model emerges, linking voxel arrangement to composite properties. This model guides the creation of voxel-level FG structures, resulting in two biomimetic constructs mimicking specific bone-soft tissue interfaces with superior mechanical properties. Additionally, the model studies the FG influence on murine preosteoblast and human bone marrow-derived mesenchymal stromal cell (hBMSC) morphology and protein expression, driving rational design of soft-hard interfaces in biomedical applications.