Water-Soluble Anthraquinone Photocatalysts Enable Methanol-Driven Enzymatic Halogenation and Hydroxylation Reactions

Journal article (2020)

Authors

Bo Yuan Xi’an Jiaotong University
Durga Mahor Xi’an Jiaotong University
Qiang Fei Xi’an Jiaotong University
Ron Wever Universiteit van Amsterdam
Miguel Alcalde Institute of Catalysis, CSIC, Madrid
Wuyuan Zhang Xi’an Jiaotong University
F. Hollmann BT/Biocatalysis - AS
Frank Hollmann BT/Biocatalysis - AS
Research Group
BT/Biocatalysis (AS) (TU Delft)
Copyright: © 2020 Bo Yuan, Durga Mahor, Qiang Fei, Ron Wever, Miguel Alcalde, Wuyuan Zhang, F. Hollmann
DOI: https://doi.org/10.1021/acscatal.0c01958
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Published Date

2020

Language

English

Faculty

Applied Sciences

Department

BT/Biotechnologie

Research Group

BT/Biocatalysis

Abstract

Peroxyzymes simply use H2O2 as a cosubstrate to oxidize a broad range of inert C-H bonds. The lability of many peroxyzymes against H2O2 can be addressed by a controlled supply of H2O2, ideally in situ. Here, we report a simple, robust, and water-soluble anthraquinone sulfonate (SAS) as a promising organophotocatalyst to drive both haloperoxidase-catalyzed halogenation and peroxygenase-catalyzed oxyfunctionalization reactions. Simple alcohols, methanol in particular, can be used both as a cosolvent and an electron donor for H2O2 generation. Very promising turnover numbers for the biocatalysts of up to 318 »000 have been achieved.